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1. Lethality Sett
- Runes: Conqueror - Triumph - Alacrity - Last Stand / Second Wind - Overgrowth - Adaptive, Adaptive, Health.
- Starting Item: Doran's Blade.
- Full Build: Eclipse / Plated Steelcaps / Edge of Night / Ghostblade / Serpent's Fang / Sundered Sky.
- Skill Order: Q -> W -> E.
2. Lethality Vayne
- Runes: Press the Attack - Triumph - Bloodline - Coup de Grace / Conditioning - Overgrowth - Attack Speed, Adaptive, Health.
- Starting Item: Doran's Blade.
- Full Build: Stormrazor / Berserker's Greaves / Essence Reaver / Voltaic Cyclosword / Lord Dominik's Regard / Rapid Firecannon.
- Skill Order: Q -> W -> E.
3. Lethality Vi
- Runes: Hail of Blades - Sudden Impact - Eyeball Collection - Ultimate Hunter / Triumph - Tenacity - Adaptive, Adaptive, Health.
- Starting Item: Blue Smite.
- Full Build: Essence Reaver / Ionian Boots / Opportunity / Eclipse / Serpent's Fants / Serylda's Grudge.
- Skill Order: Q -> E -> W.
